Figure 3. Anti-angiogenic therapy of orthotopic colorectal tumors promotes HGF-dependent metastatic dissemination.
A. Hepatic and pulmonary metastases in mice bearing HCT-116 tumors were determined by ex vivo bioluminescence (EVBL) analysis of explanted organs and by histological examination of tissue sections (inset). B. Same as in A but using mice bearing HT-29 tumors. Values represent mean ± SEM. Statistical significance was calculated using a Student's T-test (n = 7). Bar size: 250 μm.