Table 3. CXCL12 methylation proportion according to MSI, MSS and CIMP status for each CpG sites in CXCL12 nearest and within the start of CXCL12 gene.
| CpG site Target ID | Position | dTSS | CpG Island according to UCSC | % methylated in Normal Tissues | % methylated in MSI tumors | % methylated in MSS tumors | p-value (diff % MSI vs %MSS) | % methylated in CIMP+ tumors | % methylated in CIMP- tumors | p-value (diff % CIMP+ vs %CIMP- | % methylated in MSI CIMP- tumors | % methylated in MSI CIMP+ tumors | % methylated in MSS CIMP- tumors | % methylated in MSS CIMP+ tumors | p-value (diff % MSI x CIMP) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cg11267527 | 44881934 | −1389 | Island | nd | 100% | 100% | - | 100% | 100% | – | 100% | 100% | 100% | 100% | – |
| cg00499822 | 44881551 | −1006 | Island | 100% | 91% | 83% | 0.37 | 94% | 82% | 0.26 | 92% | 86% | 80% | 100% | 0.55 |
| cg18618334 | 44881054 | −509 | Island | 4% | 72% | 33% | 5.3E-04 | 90% | 24% | 2.1E-08 | 92% | 21% | 26% | 80% | 5.8E-08 |
| cg26718433 | 44880730 | −185 | Island | nd | 77% | 30% | 6.4E-05 | 94% | 27% | 7.0E-09 | 92% | 43% | 20% | 100% | 1.2E-08 |
| cg26267854 | 44880562 | −17 | Island | nd | 81% | 43% | 6.0E-04 | 97% | 39% | 1.2E-07 | 96% | 50% | 34% | 100% | 7.1E-07 |
| cg23407507 | 44880559 | −14 | Island | nd | 77% | 33% | 1.1E-04 | 94% | 29% | 2.1E-08 | 92% | 43% | 23% | 100% | 4.6E-08 |
| cg17267805 | 44880545 | 0 | Island | nd | 81% | 33% | 4.3E-05 | 97% | 31% | 5.8E-09 | 96% | 50% | 23% | 100% | 8.6E-09 |
| cg07001963 | 44879465 | 1080 | N_Shore | nd | 74% | 33% | 2.4E-04 | 97% | 22% | 2.0E-10 | 96% | 21% | 23% | 100% | 1.0E-09 |
| cg12793525 | 44875989 | 4556 | N_Shelf | nd | 100% | 100% | - | 100% | 100% | - | 100% | 100% | 100% | 100% | - |
CpGisland (UCSC, chr10:44879714-44882391).