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. 2017 Mar 3;8(24):38530–38540. doi: 10.18632/oncotarget.15869

Figure 1. CYP1A2 expression and its correlation with OS metastasis and metastatic tumor microenvironment.

Figure 1

A. Kruskal-Wallis Test (p<0.0001). Analyses between two groups were done by Mann-Whitney Test that confirmed CYP1A2 overexpression in adjacent lung to OS metastasis in comparison with normal bone (control of the bone tissue) (p=0.0015), adjacent bone to primary OS (p<0.0001) and normal lung (control of the lung tissue) (p=0.0256). B. Friedman Test (p<0.0001). Dunn's multiple comparisons test confirmed CYP1A2 overexpression in comparison with CYP3A4 (p<0.0001) and CYP3A5 (p=0.0168) in adjacent lung to OS metastasis. C. Kruskal-Wallis Test. CYP1A2 overexpression in M-OS cell line, established from OS metastasis in the lung (p=0.0464). Statistical significance: *: p<0.05; **: p<0.01; ***: p<0.001; ****: p<0.0001.