Table 3. Multivariate analysis for overall survival according to the expression of FGFR4-related genes.

Variables	Hazard ratio (95% CI)	p-value
FGF19
FGF19 (high vs. low)	0.38 (0.18–0.81)	0.012
Sex (male vs. female)	1.36 (0.52–3.55)	0.53
Age (≥ 60 years vs. < 60 years)	0.76 (0.34–1.69)	0.50
N stage (N1 vs. N0 or Nx)	1.44 (0.68–3.01)	0.35
Differentiation (poor vs. well or moderate)	0.24 (0.07–0.86)	0.029
FGF21
FGF21 (high vs. low)	0.41 (0.19–0.89)	0.024
Sex (male vs. female)	1.16 (0.44–3.03)	0.76
Age (≥ 60 years vs. < 60 years)	0.73 (0.33–1.60)	0.43
N stage (N1 vs. N0 or Nx)	1.84 (0.85–3.99)	0.13
Differentiation (poor vs. well or moderate)	0.30 (0.08–1.08)	0.065
FGFR4
FGFR4 (high vs. low)	0.32 (0.14–0.72)	0.006
Sex (male vs. female)	1.12 (0.41–3.01)	0.83
Age (≥ 60 years vs. < 60 years)	0.95 (0.44–2.16)	0.95
N stage (N1 vs. N0 or Nx)	1.90 (0.87–4.16)	0.11
Differentiation (poor vs. well or moderate)	0.30 (0.08–1.10)	0.069
KLB
KLB (high vs. low)	0.47 (0.20–1.01)	0.077
Sex (male vs. female)	1.11 (0.42–2.94)	0.84
Age (≥ 60 years vs. < 60 years)	0.81 (0.37–1.80)	0.61
N stage (N1 vs. N0 or Nx)	1.83 (0.83–4.05)	0.14
Differentiation (poor vs. well or moderate)	0.40 (0.11–1.46)	0.17

Abbreviations: CI = confidence interval.