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(A) Tumor proliferative index is correlated with TCGA breast cancer somatic mutation burden. (B) Q-Q plot of p-values derived from gene mutation burden-proliferative index associations. (C) TCGA breast tumors containing non-synonymous mutations in RELN have higher proliferative index compared to wild-type. (D) Kaplan-Meier survival plot shows reduced expression or protein-altering mutations in RELN are markers of poor prognosis in patients with basal breast cancer.
