Table 2. Meta-analysis of TERT rs2736100 T>G polymorphism on cancer risk.
| Variables | Homozygous | Heterozygous | Recessive | Dominant | Allele | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GG vs. TT | TG vs. TT | GG vs. (TG + TT) | (TG +GG) vs. TT | G vs. T | |||||||||||
| OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | |
| All | 1.39 (1.26-1.54) | <0.001 | 93.3 | 1.16 (1.11-1.23) | <0.001 | 80.0 | 1.25 (1.16-1.35) | <0.001 | 91.1 | 1.23 (1.15-1.31) | <0.001 | 88.9 | 1.17 (1.12-1.23) | <0.001 | 93.4 |
| Cancer type | |||||||||||||||
| Lung | 1.60 (1.49-1.71) | <0.001 | 65.7 | 1.25 (1.20-1.31) | 0.008 | 45.5 | 1.40 (1.32-1.48) | <0.001 | 61.2 | 1.33 (1.26-1.39) | <0.001 | 58.6 | 1.24 (1.17-1.31) | <0.001 | 89.4 |
| MPN | 3.17 (2.51-4.00) | 0.854 | 0.0 | 2.03 (1.64-2.51) | 0.972 | 0.0 | 1.89 (1.59-2.24) | 0.616 | 0.0 | 2.40 (1.97-2.94) | 0.957 | 0.0 | 1.74 (1.56-1.95) | 0.679 | 0.0 |
| AML | 1.40 (1.04-1.88) | 0.631 | 0.0 | 1.22 (0.94-1.59) | 0.744 | 0.0 | 1.23 (0.97-1.56) | 0.411 | 0.0 | 1.28 (1.00-1.64) | 0.970 | 0.0 | 1.18 (1.02-1.37) | 0.658 | 0.0 |
| Thyroid | 1.79 (1.25-2.56) | 0.076 | 68.3 | 1.26 (0.96-1.65) | 0.085 | 66.2 | 1.62 (1.37-1.92) | 0.266 | 19.3 | 1.38 (1.02-1.88) | 0.041 | 76.0 | 1.33 (1.08-1.64) | 0.040 | 76.4 |
| Gastric | 1.39 (0.82-2.33) | 0.028 | 72.1 | 1.22 (0.90-1.66) | 0.204 | 37.2 | 1.19 (0.83-1.70) | 0.044 | 68.1 | 1.31 (0.90-1.90) | 0.085 | 59.4 | 1.22 (0.94-1.58) | 0.023 | 73.5 |
| Breast | 0.56 (0.25-1.28) | <0.001 | 95.0 | 0.88 (0.73-1.07) | 0.158 | 49.8 | 0.63 (0.24-1.64) | <0.001 | 97.3 | 0.78 (0.71-0.85) | 0.892 | 0.0 | 0.80 (0.61-1.04) | 0.003 | 88.8 |
| Melanoma | 1.18 (0.90-1.54) | 0.890 | 0.0 | 1.00 (0.78-1.27) | 0.444 | 0.0 | 1.18 (0.95-1.47) | 0.700 | 0.0 | 1.06 (0.85-1.33) | 0.570 | 0.0 | 1.09 (0.95-1.26) | 0.922 | 0.0 |
| Colorectal | 0.86 (0.82-0.91) | 0.512 | 0.0 | 0.98 (0.93-1.03) | 0.989 | 0.0 | 0.88 (0.82-0.96) | 0.279 | 21.9 | 0.94 (0.90-0.98) | 0.970 | 0.0 | 0.93 (0.90-0.96) | 0.548 | 0.0 |
| Bladder | 1.31 (1.08-1.59) | 0.481 | 0.0 | 1.15 (0.98-1.34) | 0.498 | 0.0 | 1.18 (1.00-1.39) | 0.598 | 0.0 | 1.19 (1.02-1.38) | 0.436 | 0.0 | 1.13 (1.03-1.25) | 0.507 | 0.0 |
| Glioma | 1.89 (1.52-2.35) | 0.028 | 67.0 | 1.55 (1.30-1.84) | 0.055 | 60.0 | 1.35 (1.21-1.49) | 0.241 | 28.5 | 1.65 (1.37-1.99) | 0.020 | 69.4 | 1.33 (1.25-1.42) | 0.089 | 50.4 |
| Others | 1.09 (0.89-1.32) | <0.001 | 86.7 | 0.97 (0.88-1.07) | 0.002 | 58.4 | 1.11 (0.95-1.29) | <0.001 | 84.3 | 1.01 (0.89-1.13) | <0.001 | 78.2 | 1.04 (0.94-1.15) | <0.001 | 87.0 |
| Ethnicity | |||||||||||||||
| Asian | 1.56 (1.46-1.67) | <0.001 | 65.0 | 1.22 (1.17-1.28) | 0.001 | 49.5 | 1.39 (1.32-1.46) | <0.001 | 50.4 | 1.30 (1.28-1.36) | <0.001 | 62.1 | 1.25 (1.20-1.29) | <0.001 | 67.7 |
| Caucasian | 1.22 (1.04-1.44) | <0.001 | 94.4 | 1.12 (1.02-1.22) | <0.001 | 83.6 | 1.11 (0.99-1.25) | <0.001 | 92.5 | 1.16 (1.04-1.29) | <0.001 | 90.7 | 1.11 (1.03-1.19) | <0.001 | 94.2 |
| Sample Size | |||||||||||||||
| ≥ 500 | 1.34 (1.19-1.51) | <0.001 | 95.1 | 1.16 (1.09-1.23) | <0.001 | 83.7 | 1.22 (1.11-1.33) | <0.001 | 93.6 | 1.21 (1.13-1.30) | <0.001 | 91.5 | 1.15 (1.09-1.22) | <0.001 | 95.1 |
| <500 | 1.52 (1.26-1.82) | <0.001 | 72.5 | 1.19 (1.04-1.37) | <0.001 | 66.2 | 1.34 (1.19-1.51) | 0.001 | 55.1 | 1.29 (1.11-1.49) | <0.001 | 73.3 | 1.23 (1.12-1.35) | <0.001 | 74.1 |
| Score | |||||||||||||||
| High | 1.33 (1.18-1.48) | <0.001 | 94.5 | 1.15 (1.09-1.21) | <0.001 | 82.7 | 1.22 (1.12-1.33) | <0.001 | 92.8 | 1.20 (1.12-1.28) | <0.001 | 90.8 | 1.15 (1.09-1.21) | <0.001 | 94.5 |
| Low | 1.72 (1.40-2.10) | 0.001 | 60.5 | 1.30 (1.10-1.54) | 0.003 | 57.0 | 1.41 (1.26-1.59) | 0.154 | 27.4 | 1.40 (1.20-1.63) | <0.001 | 65.7 | 1.30 (1.18-1.43) | <0.001 | 60.5 |
Abbreviations: MPN, Myeloproliferative neoplasms; AML, Acute myeloid leukemia