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. 2017 Mar 17;8(24):38755–38766. doi: 10.18632/oncotarget.16333

Figure 3. Inhibition of PI3K/AKT pathway suppresses esophageal cancer cell invasion and migration.

Figure 3

(A) Human esophageal cancer cells KYSE270, T.Tn, KYSE410-I3 and KYSE510-I3 with PTEN overexpression were subjected to invasion assay. Values were then normalized to cells expressing vector control (CON). (B) Treatment with 5 μM LY294002 or 5 μM wortmannin reduced the invasive potential of KYSE270, T.Tn, KYSE410-I3, and KYSE510-I3 cells as determined by chamber invasion assay. (C) PTEN overexpression inhibited cell migration in KYSE270 and T.Tn cells as determined by chamber migration assay. (D) PI3K/AKT inhibitors, LY294002 and Wortmannin, significantly suppressed cancer cell migration in KYSE270 and T.Tn cells. Bars, SD; **, P < 0.01; ***, P < 0.001 compared with control cells.