Table 2. Correlation between miRNA score and clinical and laboratory features in pediatric and adolescent CN-AML patients (n = 59).
| Characteristics | Total | microRNA score | P-value | |
|---|---|---|---|---|
| Low (n = 30) | High (n = 29) | |||
| Age (Mean ± SD, years) | 11.5 ± 5.2 | 12.0 ± 4.7 | 10.9 ± 5.7 | 0.449 |
| Male sex-no. (%) | 36 (61.0%) | 17 (56.7%) | 19 (65.5%) | |
| WBC at diagnosis(10−9/liter)* | 69.9 (0.9–446) | 67.3 (5.1–210) | 72.5 (0.9–446) | 0.807 |
| Bone marrow blasts (%) | 71.3 (21-98) | 74.8 (21-98) | 67.5 (25–96) | 0.168 |
| Peripheral blasts (%) | 55.2 (0–97) | 67.1 (18.5–97) | 42.3 (0–95) | 0.002 |
| FAB Category | ||||
| M0 | 1 (1.7%) | 0 | 1 (3.4%) | NA |
| M1 | 16 (27.1%) | 12 (40.0%) | 4 (13.8%) | 0.049 |
| M2 | 14 (23.7%) | 8 (26.7%) | 6 (20.7%) | 0.815 |
| M4 | 13 (22.0%) | 5 (16.7%) | 8 (27.6%) | 0.486 |
| M5 | 4 (6.8%) | 2 (6.7%) | 2 (6.9%) | > 0.999 |
| NOS | 7 (11.9%) | 2 (6.7%) | 5 (17.2%) | 0.394 |
| Unknown | 4 (6.8%) | 1 (3.3%) | 3 (10.3%) | 0.580 |
*WBC at diagnosis: White Blood Cells at dignosis.