Figure 4. The inhibition of TOPK by ilaprazole is dependent on the abundance of TOPK.
Ilaprazole has less effect on anchorage-independent cell growth of shTOPK transfected cells than that of shMOCK cells. The effect of ilaprazolewas examined in shMock and knockdown cell lines with shTOPK. Cells were incubated for 48 hours and growth was determined by cck8 assay.