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. 2017 Mar 27;8(24):39154–39166. doi: 10.18632/oncotarget.16610

Figure 1. IL-6 induces cDDP resistance of EOC cells.

Figure 1

(A) Viability of EOC cells pretreated with IL-6 (20 ng/ml) for 72 h in response to an increasing concentration of cDDP. (B) IC50 for cDDP in EOC cells treated with IL-6 (20 ng/ml). A2780 cells were intraperitoneally injected into BALB/c nude mice (n=6), which were then treated with recombinant IL-6 for 5 weeks. (C) Representative images showing the formation of tumors in mice. (D) Tumor incidence in indicated mice. (E) Total tumor weight per mouse. (F) Western blotting analysis of IL-6R, p-STAT3 and STAT3 in EOC cell lines after IL-6 treatment. (G) Cell viability of EOC cells transfected with siIL-6R or siSTAT3 following with IL-6 stimulation. (H) IC50 for cDDP in EOC cells after transfection. *P< 0.05, **P< 0.01.