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. 2017 Mar 27;8(24):39154–39166. doi: 10.18632/oncotarget.16610

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Copyright: © 2017 Zhu et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Relative miR-204 (A) or IL-6R (B) levels in patient tumor specimens with progression-free survival (PFS) <6 months versus PFS >6 months. (C) Immunohistochemistry analysis of IL-6, IL-6R, and p-STAT3 in ovarian cancer specimens obtained from cDDP-sensitive (PFS<6) and cDDP-resistant (PFS>6) patients. Representative images are shown (200x magnification). (D) Western blotting analysis of IL-6, IL-6R, p-STAT3, and STAT3 in patient tumor specimens with PFS<6 months (tissues from 4 patients mixed into 1 sample, n=16) versus PFS>6 months (tissues from 12 patients mixed into 1 sample, n=48). A Kaplan-Meier analysis of the PFS of patients with ovarian cancer with the corresponding expression profiles of IL-6R (E) and miR-204 (F) is shown. (G) IL-6R and miR-204 expression were inversely correlated in ovarian cancer samples (n=64). (H) A plot of the relative expression of miR-204 vs. IL-6R showed an inverse correlation between IL-6R and miR-204 expression. The correlation index, R², was calculated using the Spearman rank test (R²=0.404, P<0.001). (I) A Kaplan-Meier analysis for the PFS of ovarian cancer patients according to anticorrelation miR-204 and IL-6R expression. **P< 0.01.