Table 5. Stratified analyses between PD-1 rs10204525 T>C polymorphism and EGJA risk by sex, age, smoking status and alcohol consumption.

Variable	PD-1 rs10204525 T>C (case/control) a			Adjusted OR b (95% CI); P
	TT	TC	CC	TT	TC	CC	TC / CC	CC vs. (TC/TT)
Sex
Male	384/621	289/476	71/94	1.00	0.96 (0.79–1.17); P: 0.704	1.20 (0.86–1.67); P: 0.294	1.04 (0.86–1.25); P: 0.700	1.24(0.90–1.72); P: 0.194
Female	160/249	108/196	27/38	1.00	0.79(0.58–1.08); P: 0.140	1.08 (0.63–1.85); P: 0.776	0.89(0.66–1.19); P: 0.422	1.23 (0.73–2.08); P: 0.433
Age
<64	245/442	187/310	50/71	1.00	1.04 (0.82–1.33); P: 0.725	1.26 (0.85–1.87); P: 0.260	1.13(0.90–1.42); P: 0.283	1.27 (0.86–1.86); P: 0.226
≥64	299/428	210/362	48/61	1.00	0.80 (0.64–1.01); P: 0.055	1.10 (0.73–1.66); P: 0.640	0.88 (0.71–1.09); P: 0.237	1.24 (0.83–1.84); P: 0.291
Smoking status
Never	385/679	300/534	68/108	1.00	0.94(0.78–1.13); P: 0.505	1.08(0.78–1.50); P: 0.644	1.01 (0.84–1.21); P: 0.926	1.14 (0.83–1.57); P: 0.419
Ever	159/191	97/138	30/24	1.00	0.84 (0.60–1.18); P: 0.321	1.60 (0.89–2.88); P: 0.115	0.97 (0.71–1.33); P: 0.849	1.74 (0.98–3.08); P: 0.058
Alcohol consumption
Never	464/774	339/610	83/121	1.00	0.89(0.74–1.05); P: 0.171	1.11 (0.82–1.50); P: 0.508	0.96 (0.82–1.14); P: 0.660	1.20(0.89–1.61); P: 0.230
Ever	80/96	58/62	15/11	1.00	1.11 (0.68–1.79); P: 0.680	2.22(0.91–5.43); P: 0.080	1.26 (0.80–1.99); P: 0.328	2.14 (0.89–5.10); P: 0.088

^aThe genotyping was successful in 1063 (97.74%) EGJA cases, and 1677 (99.82%) controls for PD-1 rs10204525 T>C;

^bAdjusted for age, sex, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.