Table 7. Stratified analyses between PD-1 rs7421861 A>G polymorphism and EGJA risk by sex, age, smoking status and alcohol consumption.

Variable	PD-1 rs7421861 A>G (case/control)a			Adjusted OR b (95% CI); P
	AA	AG	GG	AA	AG	GG	AG/GG	GG vs. (AG/AA)
Sex
Male	455/819	262/331	29/41	1.00	1.40 (1.15–1.70); P: 0.001	1.20 (0.74–1.97); P: 0.462	1.41 (1.16–1.71); P: 0.001	1.10 (0.67–1.79); P: 0.712
Female	187/347	96/123	12/13	1.00	1.37 (0.99–1.89); P: 0.058	1.65 (0.73–3.69); P: 0.228	1.46 (1.07–2.00); P: 0.017	1.55(0.69–3.46); P: 0.286
Age
<64	286/590	173/212	23/21	1.00	1.62 (1.27–2.08); P: < 0.001	2.07 (1.12–3.83); P: 0.021	1.73 (1.36–2.20); P: < 0.001	1.82 (0.99–3.35); P: 0.054
≥64	356/576	185/242	18/33	1.00	1.21 (0.96–1.53); P: 0.108	0.87 (0.48–1.56); P: 0.633	1.20 (0.96–1.50); P: 0.113	0.83 (0.46–1.49); P: 0.531
Smoking status
Never	465/925	263/353	26/43	1.00	1.42 (1.17–1.73); P: < 0.001	1.16 (0.70–1.92); P: 0.558	1.45 (1.20–1.75); P: < 0.001	1.07 (0.65–1.75); P: 0.804
Ever	177/241	95/101	15/11	1.00	1.29 (0.91–1.82); P: 0.149	1.85 (0.82–4.17); P: 0.139	1.36 (0.98–1.90); P: 0.068	1.72 (0.77–3.85); P: 0.188
Alcohol consumption
Never	544/1050	311/408	32/47	1.00	1.42 (1.19–1.70); P: < 0.001	1.26 (0.80–2.00); P: 0.326	1.46 (1.22–1.73); P: < 0.001	1.15 (0.73–1.82); P: 0.541
Ever	98/116	47/46	9/7	1.00	1.14 (0.69–1.89); P: 0.609	1.73 (0.59–5.09); P: 0.322	1.21 (0.75–1.95); P: 0.441	1.66 (0.57–4.83); P: 0.356

^a The genotyping was successful in 1063 (97.93%) EGJA cases, and 1677 (99.82%) controls for PD-1 rs7421861 A>G;

^b Adjusted for age, sex, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.