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. 2017 Apr 5;8(24):39218–39229. doi: 10.18632/oncotarget.16836

Figure 2. Depletion of Btk inhibits macrophage production of homeostatic chemokines and angiogenic cytokines.

Figure 2

(A & B) THP-1 differentiated macrophages were transfected with Btk siRNA for 48 hours and then stimulated with LPS (1 μg/ml) for 18 hours. The chemokine and cytokine production from macrophages were measured by ELISA. (C) Total RNA was extracted, and the expression of mRNA was detected by real time PCR. *Significantly decreased compared to LPS treatment alone (p < 0.05). Results are representative of three similar experiments.