Table 1. The six SNPs significantly (P < 1.21 × 10−6) associated with BMI in the EWAS.
Gene | dbSNP | Nucleotide (amino acid) substitutiona | Chromosome: position | MAF (%) | P (genotype) |
---|---|---|---|---|---|
rs633715 | T/C | 1: 177883445 | 22.0 | 8.33 × 10−8 | |
rs543874 | A/G | 1: 177920345 | 21.9 | 1.36 × 10−7 | |
FTO | rs1421085 | T/C | 16: 53767042 | 19.1 | 5.37 × 10−7 |
FTO | rs1558902 | T/A | 16: 53769662 | 19.1 | 6.67 × 10−7 |
FTO | rs8050136 | C/A | 16: 53782363 | 19.2 | 1.08 × 10−6 |
FTO | rs9939609 | T/A | 16: 53786615 | 19.3 | 1.13 × 10−6 |
The relation of genotypes of SNPs to BMI was evaluated by linear regression analysis. aMajor allele/minor allele.