Table 3. Summary of OR and 95% CI for association of rs144848 polymorphism with cancer risk by cancer type stratification.
Subgroup | p for heterogeneity | I2 (%) | OR (95% CI) | p value | Effects model |
---|---|---|---|---|---|
N allele vs H allele | |||||
Breast cancer | 0.679 | 0.0 | 1.028 (0.997-1.060) | 0.075 | fixed |
Ovarian cancer | 0.359 | 9.1 | 1.024 (0.981-1.068) | 0.280 | fixed |
NHL | 0.518 | 0.0 | 1.110 (1.023-1.205) | 0.012a | fixed |
Others | 0.658 | 0.0 | 1.158 (1.074-1.249) | <0.001a | fixed |
NH vs NN | |||||
Breast cancer | 0.890 | 0.0 | 1.029 (0.988-1.072) | 0.166 | fixed |
Ovarian cancer | 0.080 | 46.8 | 1.015 (0.959-1.074) | 0.604 | fixed |
NHL | 0.954 | 0.0 | 1.090 (0.977-1.215) | 0.122 | fixed |
Others | 0.090 | 47.5 | 1.117 (1.009-1.236) | 0.033a | fixed |
HH vs NN | |||||
Breast cancer | 0.491 | 0.0 | 1.056 (0.978-1.139) | 0.162 | fixed |
Ovarian cancer | 0.446 | 0.0 | 1.063 (0.957-1.180) | 0.253 | fixed |
NHL | 0.294 | 19.0 | 1.263 (1.035-1.542) | 0.022a | fixed |
Others | 0.653 | 0.0 | 1.439 (1.199-1.726) | <0.001a | fixed |
Dominant model | |||||
Breast cancer | 0.852 | 0.0 | 1.033 (0.994-1.074) | 0.097 | fixed |
Ovarian cancer | 0.156 | 35.7 | 1.022 (0.969-1.079) | 0.420 | fixed |
NHL | 0.855 | 0.0 | 1.118 (1.008-1.240) | 0.035a | fixed |
Others | 0.237 | 26.3 | 1.162 (1.055-1.280) | 0.002a | fixed |
Recessive model | |||||
Breast cancer | 0.477 | 0.0 | 1.044 (0.969-1.124) | 0.259 | fixed |
Ovarian cancer | 0.351 | 10.3 | 1.057 (0.954-1.170) | 0.290 | fixed |
NHL | 0.277 | 21.6 | 1.216 (1.002-1.476) | 0.048a | fixed |
Others | 0.377 | 6.2 | 1.346 (1.130-1.603) | 0.001a | fixed |
a Statistically significant