Table 5. Summary of OR and 95% CI for association of rs144848 polymorphism with breast cancer risk by the study design stratification.
| Subgroup | p for heterogeneity | I2 (%) | OR (95% CI) | p value | Effects model |
|---|---|---|---|---|---|
| H allele vs N allele | |||||
| PB | 0.691 | 0.0 | 1.034 (1.000-1.068) | 0.047a | fixed |
| HB | 0.759 | 0.0 | 0.883 (0.707-1.103) | 0.273 | fixed |
| Others | 0.264 | 24.5 | 1.011 (0.923-1.108) | 0.810 | fixed |
| NH vs NN | |||||
| PB | 0.953 | 0.0 | 1.030 (0.986-1.076) | 0.182 | fixed |
| HB | 0.684 | 0.0 | 0.864 (0.638-1.171) | 0.346 | fixed |
| Others | 0.174 | 39.6 | 1.050 (0.930-1.186) | 0.428 | fixed |
| HH vs NN | |||||
| PB | 0.315 | 12.4 | 1.076 (0.991-1.168) | 0.082 | fixed |
| HB | 0.677 | 0.0 | 0.844 (0.501-1.422) | 0.525 | fixed |
| Others | 0.559 | 0.0 | 0.957 (0.763-1.200) | 0.702 | fixed |
| Dominant model | |||||
| PB | 0.916 | 0.0 | 1.037 (0.995-1.081) | 0.085 | fixed |
| HB | 0.750 | 0.0 | 0.856 (0.642-1.141) | 0.290 | fixed |
| Others | 0.195 | 36.2 | 1.035 (0.922-1.162) | 0.558 | fixed |
| Recessive model | |||||
| PB | 0.297 | 14.0 | 1.063 (0.982-1.151) | 0.132 | fixed |
| HB | 0.625 | 0.0 | 0.867 (0.538-1.398) | 0.558 | fixed |
| Others | 0.627 | 0.0 | 0.943 (0.757-1.175) | 0.600 | fixed |
a Statistically significant