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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Environ Res. 2017 Apr 26;156:619–624. doi: 10.1016/j.envres.2017.04.025

Table 3.

Change in methylation and expression over 6 month was not associated with change in mouse IgE over 12 month

Change in
FOXP3 		Enhancer CpG−138 CpG−126 Expression
B −0.01 −0.01 −0.02 −0.03
SE 0.01 0.004 0.01 0.03
Change in IFNγ CppG-186 CpG-54 Expression
B −0.002 0.004 0.02
SE 0.01 0.01 0.04

B: Estimated regression coefficient. SE: Standard error

Relative expression of FOXP3 was measured using log transformation (variable+0.1)

Relative expression of IFNγ was measured using log transformation (variable+0.5)

Analyses controlled for both mouse allergen at baseline (natural log transformed) and CpG methylation or gene expression at baseline. Sensitivity analyses of gene expression including only those with qRT-PCR cycle length <37 did not alter the results.

N=179 for all analyses, with specimens excluded due to lack of 12 month blood specimen (n=12 samples from 11 individuals), or inadequate or pyrosequencing reactions failed (up to n=15 for IFNγ methylation analyses).