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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 May 4;37(7):1352–1360. doi: 10.1161/ATVBAHA.116.308895

Figure 5. JAK3 mediated PDGF-BB function in activating signal transducer and activator of transcription 3 (STAT3) and c-Jun N-terminal kinase (JNK).

Figure 5

A, Janex-1 attenuated PDGF-BB-induced phosphorylation of STAT3 and JNK. B and C, Quantification of pSTAT3 and pJNK protein expression shown in A by normalizing to α-Tubulin level. *P < 0.05 vs vehicle-treated cells (−); #P < 0.05 vs PDGF-BB-treated groups for each individual protein, respectively, n=3. D, Knockdown of JAK3 by shRNA (Ad-shJAK3) attenuated PDGF-BB-induced STAT3 and JNK phosphorylation. E and F, Quantification of pJAK3, pSTAT3 and pJNK levels shown in D by normalizing to α-Tubulin level, respectively. *P < 0.05 vs scramble shRNA (Ad-shScr)-transduced cells; #P < 0.05 vs Ad-shScr-transduced cells with PDGF-BB, for each individual protein, respectively, n=3.