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. 2017 Apr 19;31(8):3349–3358. doi: 10.1096/fj.201601303R

Figure 1.

Figure 1.

Normal mDAN morphology and number in tau-deficient mouse embryos at E14.5. A) TH immunohistochemistry of midbrains of E14.5 Mapt+/+, Mapt+/−, and Mapt−/− mice. Representative coronal sections of midbrain, rostral to caudal, are shown, with white dotted lines demarcating the presumptive (Pre) boundary between the SN and VTA. The lateral TH+ area is considered to be Pre-SN, whereas the intermediate is Pre-VTA. Scale bar, 100 μm. B) The number of TH+ neurons in the Pre-SN, Pre-VTA, and total midbrain of E14.5 mice (n = 5 for each genotype vs. control littermates). Data are means ± sem.