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A) Structure of glucose-bound KLrP. B) Model of KL1 domain overlaid with glucose-bound KLrP showing modeled KL1 domain is structurally similar to KLrP domain. C) Model structure of sKlotho KL1 domain showing central parallel core of β strands (green) stabilized by α helixes (cyan); other β sheets and α helices and loops in light gray. D) Model structure of KL1 domain with residues in KLrP that bind to glucose mapped to corresponding residues in Klotho KL1 domain (red).
