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α2-3-Sialyllactose bound to modeled sKlotho KL1 domain. A) Binding site contains multiple charged and hydrophobic residues seen in X-ray structures of α2-3-sialyllactose-bound proteins in Fig. 1. B) Hydrogen bonds (dashed lines) formed by α2-3-sialyllactose with KL1 domain from #1 docked conformation. C) Hydrogen bonds formed by highly conserved KL1 residues with α2-3-sialyllactose. D) Hydrogen bonds formed by variable KL1 residues with α2-3-sialyllactose.
