Table 2.
High frequency ventilation vs. conventional mechanical ventilation for lung rest–demographics and clinical characteristics
| Characteristic | Data Available N (%) |
Overall N = 3040 |
HFV N = 363 |
CMV N = 2677 |
|---|---|---|---|---|
| Gestational age (weeks) | 2783 (91.5) | 39 (38, 40) | 39 (38, 40) | 39 (38, 40) |
| Birth weight (kg) | 2783 (91.5) | 3.3 (2.9, 3.7) | 3.34 (3, 3.8) | 3.3 (2.9, 3.7) |
| Female gender (%) | 3021 (99.4) | 1299 (43) | 171 (47) | 1128 (42) |
| APGAR < 5 at 5 min (%) | 2666 (87.7) | 492 (18.5) | 56 (18) | 436 (18) |
| Day of life at time of ECMO initiation | 3040 (100) | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) |
| Hours of mechanical ventilation prior to ECMO | 2913 (95.8) | 33 (17, 62.5) | 34 (18, 63) | 33 (17, 62) |
| CMV ventilator type pre-ECMO (%) | 2796 (92) | 929 (30.6) | 15 (4.4) | 914 (37)a |
| pH | 2978 (98) | 7.21 (7.1, 7.31) | 7.18 (7.07, 7.29) | 7.22 (7.1, 7.32)a |
| RSS (MAP * FiO2) | 2441 (80) | 18 (15, 22) | 20 (17, 23) | 18 (15, 21)a |
| Oxygenation index | 2409 (79) | 48 (34, 68) | 54 (39, 77) | 47 (33, 67)a |
| MBP prior to ECMO (mmHg) | 1995 (65.6) | 43 (36, 52) | 40 (34, 49) | 44 (36, 52)a |
| Pump flow at 24h on ECMO (ml/kg/min) | 2853 (93.8) | 107 (95, 125) | 106 (95, 125) | 107 (95, 126) |
| VV ECMO (%) | 3024 (99.5) | 1204 (39.8) | 130 (36) | 1074 (40)a |
Data presented as median (interquartile ranges) or number (percentage);
a
P < 0.05
High frequency ventilation (HFV); conventional mechanical ventilation (CMV); extracorporeal membrane oxygenation (ECMO); respiratory severity score (RSS); mean airway pressure (MAP); fraction of inspired oxygen (FiO2); mean arterial blood pressure (MBP); venovenous (VV)