Table 3.

High frequency ventilation vs. conventional mechanical ventilation for lung rest–duration of extracorporeal membrane oxygenation and mechanical ventilation after decannulation in survivors

Characteristic	Data Available N (%)	Overall N = 2354	HFV N = 259	CMV N = 2095	Adjusted Odds Ratio (95% CI)
ECMO hours in survivors [median (IQR)]	2328 (98.9)	128 (93, 183)	150.5 (111, 222)	126 (92, 178)	1.52 (1.02, 2.3)a
Adjusted ECMO hours in survivors (mean ± SEM)			150.2 ± 0.05	125 ± 0.02 b
Hours of mechanical ventilation after decannulation in survivors [median (IQR)]	1841 (78.2)	106 (56, 189)	134 (84, 242)	100 (52, 178)	1.9 (1.2, 2.9)a
Adjusted duration of mechanical ventilation after decannulation in survivors (mean ± SEM)			135 ± 0.09	100.2 ± 0.03b

^aP < 0.05

^bP < 0.01

The variables included in the model: gestational age, birth weight, age at time of initiation of ECMO, APGAR score of less than 5 at 5 minutes, duration of mechanical ventilation prior to ECMO initiation, RSS, OI, pH, MBP, ECMO pump flow at 24 hours after ECMO initiation, and ECMO mode.

HFV, high frequency ventilation; CMV, conventional mechanical ventilation; CI, confidence interval; ECMO, extracorporeal membrane oxygenation; IQR, interquartile range; SEM, standard error of mean; RSS, respiratory severity score; OI, oxygenation index