Table 4.
Low vs. mid vs. high positive end expiratory pressure for lung rest–demographics and clinical characteristics
| Characteristic | Data Available N (%) |
Overall N=2557 |
Low PEEP N=841 |
Mid PEEP N=574 |
High PEEP N=1142 |
|---|---|---|---|---|---|
| Gestational age (weeks) | 2376 (93) | 39 (38, 40) | 39 (38, 40) | 39 (38, 40) | 39 (38, 40) |
| Birth weight (kg) | 2364 (92) | 3.3 (2.9, 3.7) | 3.27 (2.9, 3.7) | 3.24 (2.9, 3.7) | 3.32 (3, 3.7) a |
| Female gender (%) | 2543 (99) | 1082 (42) | 347 (41) | 252 (44) | 483 (42) |
| APGAR < 5 at 5 min (%) | 2262 (88) | 415 (18) | 130 (17) | 82 (16) | 203 (21) a |
| Day of life at time of ECMO initiation | 2557 (100) | 2 (1, 3) | 2 (1, 3) | 2 (1, 4) | 2 (1, 3) |
| Hours of mechanical ventilation prior to ECMO | 2460 (96) | 33 (17, 62) | 33 (16, 61) | 34 (17, 70) | 33 (17, 59) |
| CMV ventilator type pre-ECMO (%) | 2348 (92) | 885 (38) | 326 (42) | 197 (37) | 362 (35) a |
| pH | 2506 (98) | 7.22 (7.1, 7.32) | 7.23 (7.1, 7.33) | 7.2 (7.09, 7.32) | 7.22 (7.11, 7.31) |
| RSS (MAP * FiO2) | 1542 (79) | 18 (14, 21) | 17 (14, 20) | 18 (15, 20) | 18 (15, 22)a |
| Oxygenation index | 1993 (78) | 46 (33, 66) | 44.8 (33, 65) | 46 (33, 65) | 48 (34, 67) |
| MBP prior to ECMO (mmHg) | 1706 (67) | 44 (36, 52) | 44 (35, 52) | 42 (35, 49) a | 44 (38, 53) |
| Pump flow at 24h on ECMO (ml/kg/min) | 2538 (99) | 108 (96, 127) | 110 (96, 128) | 108 (97, 127) | 107 (95,129) |
| VV ECMO (%) | 2546 (99) | 1032 (40) | 315 (38) | 290 (50)a | 427 (38) |
| Mortality (%) | 2557 (100) | 539 (21) | 172 (20) | 122 (21) | 245 (21) |
Data presented as median (interquartile ranges) or number (percentage);
a
P < 0.05
PEEP, positive end expiratory pressure; ECMO, extracorporeal membrane oxygenation; CMV, conventional mechanical ventilation; RSS, respiratory severity score; MAP, mean arterial pressure; FiO2, fraction of inspired oxygen; MBP, mean arterial blood pressure; VV, venovenous