Table 5.

Low vs. mid vs. high positive end expiratory pressure for lung rest–duration of extracorporeal membrane oxygenation and mechanical ventilation after decannulation in survivors

Characteristic	Data Available N (%)	Overall N = 2018	Low PEEP N = 669	Mid PEEP N =452	High PEEP N = 897	Adjusted Odds Ratio (95% CI) Mid PEEP vs. Low PEEP	Adjusted Odds ratio (95% CI) High PEEP vs. Low PEEP
ECMO hours in survivors [median (IQR)]	1999 (99.1)	127 (92, 180)	142 (99, 192)	121 (93, 174)	120 (85, 166)	0.61 (0.4, 0.9)a	0.47(0.3, 0.7)c
Adjusted ECMO hours in survivors (mean ± SEM)			156 ± 1.06	141 ± 1.06	136 ± 1.05 b
Hours of mechanical ventilation after decannulation in survivors [median (IQR)]	1574 (78)	101.5 (56, 193)	97 (49, 188.5)	95 (53, 152)	115 (67.75, 205.25)	0.9 (0.7,1.5)	1.0 (0.7, 1.5)
Adjusted duration of mechanical ventilation after decannulation in survivors (mean ± SEM)			103 ± 1.12	105 ± 1.12	114 ± 1.11

^aP < 0.05

^bP < 0.01

^cP < 0.001

The variables included in the model: gestational age, birth weight, age at time of initiation of ECMO, APGAR score of less than 5 at 5 minutes, duration of mechanical ventilation prior to ECMO initiation, RSS, OI, pH, MBP, ECMO pump flow at 24 hours after ECMO initiation, and ECMO mode. PEEP, positive end expiratory pressure; CI, confidence interval; ECMO, extracorporeal membrane oxygenation; IQR, interquartile range; SEM, standard error of mean; RSS, respiratory severity index; OI, oxygenation index; MBP, mean arterial blood pressure