Table 3.
Distribution of different pfcrt and pfmdr1 haplotype in relation to in vivo CQ treatment efficacy and in vitro CQ susceptibility in Kolkata and Purulia before new national drug policy.
| Year |
pfcrt haplotype |
Pfmdr1 haplotype |
No of isolates |
CQ treatment efficacy |
In vitro CQ response |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (72–76) | 86,184, 10 34, 1042, 1246 | K | P | ACPR K | ACPR P | ETFK | ETFP | LTFK | LTFP | S K | S P | R K | R P | |
| 2008 | CVMNK | NYSND | 19 | 13 | 19 | 13 | – | – | – | – | 19 | 13 | – | – |
| CVMNK | YYSND | 2 | 6 | 2 | 6 | – | – | – | – | 1 | 2 | 1 | 4 | |
| SVMNT | NYSND | 6 | 3 | 4 | 2 | 1 | 1 | 1 | 1 | – | 5 | 3 | ||
| CVMNT | NYSND | 4 | 6 | 4 | 6 | – | – | – | 2 | 1 | 2 | 5 | ||
| CVMNT | YYSND | 7 | 3 | 2 | 2 | 4 | 1 | 1 | – | 1 | – | 6 | 3 | |
| CVMNT | NYSDD | 4 | – | 3 | – | 1 | – | – | – | 1 | – | 3 | – | |
| CVMNT | YYSNY | 10 | 4 | 2 | 1 | 7 | 3 | 1 | – | 1 | – | 9 | 4 | |
| SVMNT | NYSNY | 3 | 3 | 1 | 3 | 1 | – | 1 | – | – | – | 3 | 3 | |
| SVMNT | YYSND | 7 | 4 | 1 | 3 | 4 | – | 2 | 1 | – | – | 7 | 4 | |
| CVMNK | YYSNY | – | 23 | – | 4 | – | 17 | – | 2 | – | 2 | – | 21 | |
| SVMNT | YYSNY | – | 10 | – | 1 | – | 7 | – | 2 | – | – | – | 10 | |
| 2009 | CVMNK | NYSND | 21 | 5 | 21 | 5 | – | – | – | – | 21 | 5 | – | – |
| SVMNT | NYSND | 7 | 21 | 4 | 17 | 1 | – | 2 | 4 | 2 | 1 | 5 | 20 | |
| CVMNK | YYSNY | – | 37 | – | 5 | – | 26 | – | 6 | – | 4 | – | 33 | |
| CVIEK | YYSNY | – | 11 | – | 1 | – | 8 | – | 2 | – | 1 | – | 10 | |
| CVIET | YYSND | 3 | 4 | – | 2 | 3 | 1 | – | 1 | – | – | 3 | 4 | |
| CVMNT | YYSND | 11 | 12 | 2 | 11 | 6 | 1 | 3 | – | 1 | 4 | 10 | 8 | |
| SVMNT | NYSDD | 5 | – | 5 | – | – | – | – | – | – | – | 5 | – | |
| CVMNT | YYSNY | 15 | 3 | 3 | – | 11 | 3 | 1 | – | – | – | 15 | 3 | |
| SVMNT | NYSNY | 5 | 5 | 4 | 5 | 1 | 1 | 1 | 4 | 4 | ||||
| SVMNT | YYSND | 6 | 14 | 1 | 9 | 3 | 3 | 2 | 2 | 1 | – | 5 | 14 | |
| SVMNT | NFSND | 2 | – | – | – | 1 | – | 1 | – | – | – | 2 | – | |
| CVMNT | NYSND | – | 12 | – | 10 | – | 1 | – | 1 | – | 5 | – | 7 | |
| CVMNT | NYSNY | – | 2 | – | 2 | – | – | – | – | – | 2 | – | – | |
| Total | 137 | 201 | 78 | 108 | 43 | 71 | 16 | 22 | 52 | 41 | 85 | 160 | ||
Bold and underline amino acid are the mutant codon. Here in vitro test responses are classified as sensitive (S) (IC50 value < 100 nM) and Resistant (R) (IC50 value > 100 nM). Here K denotes for Kolkata and P denotes Purulia.