Table 1. Associations between FGF21 and Atherosclerotic Risk Factors.

Risk factor	Result	Reference
Obesity	BMI correlated positively with serum FGF21	[28]
T2DM	Elevated plasma FGF21	[29]
	Elevated plasma FGF21 predicted diabetes development	[30]
Hypertension	Independently associated with elevated serum FGF21	[31]
Dyslipidaemia	Serum FGF21 correlated positively with serum TG	[37]
	Serum FGF21 correlated positively with total cholesterol	[37]
	Serum FGF21 correlated negatively with HDL-C	[22]
	rs2071616 SNP in FGFR2 gene was associated with LDL-C	[38]
NAFLD	Elevated hepatic FGF21 expression	[32]
	Elevated serum FGF21	[33,34]
Diabetic nephropathy	Elevated baseline serum FGF21 was associated with and predicted decline of renal function	[35]
CKD	Elevated serum FGF21	[36]

FGF21, fibroblast growth factor 21; BMI, body mass index; T2DM, type 2 diabetes mellitus; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; SNP, single nucleotide polymorphism; FGFR2, FGF receptor 2; LDL-C, low density lipoprotein cholesterol; NAFLD, non-alcohol fatty liver disease; CKD, chronic kidney disease.