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. 2017 Jul 10;7:4971. doi: 10.1038/s41598-017-05154-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier estimates of probabilities of progression-free survival and overall survival in patients with non-small cell lung cancer at the follow-up times*. As shown in panels (A,B,C and D), the follow-up time for the study was 5 years. We defined NSCLC patients with PPB-CTC density >5 CTCs/15 mL as the high-risk group and those with ≤5 CTCs/15 mL as the low-risk group. Panel A shows the probability of TFS according to the PPB-CTCs; the median TFS was 22.0 months for high-risk patients and >60 months for low-risk patients, p = 0.001 via the log-rank test; Panel B shows the probability of OS according to the PPB-CTCs; the median was 27.0 months for high-risk patients and >60 months for low-risk patients, p = 0.001 via the log-rank test. Using the IPVB specimens, we defined the patients with IPVB-CTC density > 25 CTC/15 mL as the high-risk group and those with IPVB-CTC density ≤25 CTCs/15 mL as the low-risk group. Panel C shows the probability of TFS according to the IPVB-CTCs; the median was 25.0 months for high-risk patients and >60.0 months for low-risk patients, p = 0.002 via the log-rank test. Panel D shows the probability of OS according to the IPVB-CTCs; the median was 30.0 months for high-risk patients and >60.0 months for low-risk patients, p = 0.002 via the log-rank test. Abbreviations: TFS: tumor-free survival; OS: over-survival; PPB-CTCs: peripheral blood circulating tumor cells; IPVB-CTCs: pulmonary venous blood circulating tumor cells.