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. 2017 Jul 10;7:4942. doi: 10.1038/s41598-017-05232-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shorter and smaller mitochondria predominate in amoeboidal microglia in demyelinated cerebellar white matter obtained from mice overexpressing proteolipid protein (PLP). Light micrographs of Iba1 immunostaining in the cerebella of 5-month-old wild-type (WT, a,b) and PLP-overexpressing (PLPtg, c–f) mice. Immunocontrol sections are also shown (e,f). In immunoelectron micrographs (EM) with DAB deposits for Iba1 (g,h, arrows), the area indicated with a rectangle (g) is magnified (h). Single electron micrographs (i,j) and 3D reconstructions of nuclei (k,l) and mitochondria (m,n) of Iba1-positive cells in the cerebellar white matter of WT (i,k,m) and PLPtg (j,l,n) mice are shown and mitochondrial length (o) and volume (p) were statistically compared. Long and short mitochondria are colored in blue and magenta, respectively (m,n). ***p < 0.001 in the U-test. N = 68 or 506 for mitochondria in WT or PLPtg microglia. Bars: 50 μm (a,c,e), 20 μm (b,d,f), 2.5 μm (g–j).