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. 2017 Jul 10;7:4942. doi: 10.1038/s41598-017-05232-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron microscopic 3D reconstructions showing mitochondrial fragmentation and subsequent elongation with network restoration in cultured microglia after a stimulation with lipopolysaccharide (LPS). Cultured microglia with or without the LPS stimulation (a, i) were fixed and embedded in resins to image with SBF-SEM (a, ii) and mitochondria were reconstructed from the serial images (a, iii). Mitochondria with typical cristae (b, yellow) were reconstructed and colored (c,d) in cultured microglia not stimulated with LPS (Control, c) and 2 hr after the LPS stimulation (d, LPS 2hr). Measurements of length (e) and branch number (f) are shown. Long and short mitochondria are colored in blue and pink, respectively (c,d). ***p < 0.001 in the U-test. Bars: 5 μm.