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. 2017 Jul 10;7:5008. doi: 10.1038/s41598-017-05264-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Qualitative and quantitative analyses of ETBF and NTBF metabolites identified in B. fragilis cells and OMVs. (A) Qualitative analysis of metabolites identified in OMVs (external histogram), ETBF cells (middle histogram) and NTBF cells (internal histogram). Metabolites involved in certain metabolic pathways are represented as percentages of the total number of identified in ETBF OMVs/cells and NTBF OMVs/cells metabolites. (B–D) The Box plots show the quantitative differences of the amounts of several metabolites identified in ETBF and NTBF OMVs.