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. 2017 Jul 10;7:4982. doi: 10.1038/s41598-017-05226-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TGF-β2 stimulates Fgf23 gene expression and FGF23 protein synthesis in UMR106 cells. Arithmetic means ± SEM (n = 7) of (A) Fgf23 mRNA abundance (relative to Tbp mRNA) and (B) FGF23 (C-terminal) protein concentration (pg/ml) in the cell culture medium of UMR106 cells incubated without (ctrl, white bars) or with TGF-β2 (black bars, 10 ng/ml, 24 h). **p < 0.01, ***p < 0.001 indicate significant difference compared to UMR106 cells treated with vehicle only (paired t-test). (C) Arithmetic mean ± SEM (n = 5) of Fgf23 mRNA levels (relative to Tbp mRNA) in UMR106 cells after 24-hour treatment without (ctrl, white bar) or with TGF-β2 (0.3–10 ng/ml, black bars). ***p < 0.001 indicates significant difference compared to UMR106 cells treated with vehicle only (ANOVA).