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. 2017 Jul 10;7:4951. doi: 10.1038/s41598-017-04221-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Landscape of the significantly mutated genes in ESCC. Top: four datasets. Left: SMGs were sorted according to mutation frequency in 442 patients, total number of somatic mutations of each gene, and the percentages indicated the fraction of patients with the individual mutation. Genes marked with an asterisk have a q value of <0.2 in the MutSigCV analysis. Middle: mutations in 26 frequently mutated genes across 442 ESCC samples. Each column represents an individual, each row represents a gene, and mutation subtypes are denoted by color.