Table 2.
Change in each parameter before and after tafluprost initiation.
| baseline | 1 week | 4 weeks | 12 weeks | post hoc analysis, comparison with baseline* | ||||
|---|---|---|---|---|---|---|---|---|
| repeated measures ANOVA | 1 week | 4 weeks | 12 weeks | |||||
| pBFV (mm/sec) | 1.05 ± 0.16 | 1.21 ± 0.26 | 1.28 ± 0.24 | 1.19 ± 0.21 | P < 0.001 | P = 0.007† | P < 0.001† | P = 0.002† |
| MBRT (AU) | 11.8 ± 2.7 | 12.2 ± 3.1 | 12.3 ± 3.3 | 11.9 ± 3.2 | P = 0.14 | |||
| RVDA (μm) | 98.0 ± 12.4 | 98.5 ± 13.1 | 98.6 ± 13.5 | 93.7 ± 11.6 | P = 0.37 | |||
| RVDV (μm) | 131.9 ± 11.7 | 133.6 ± 13.7 | 135.7 ± 15.3 | 134.8 ± 16.7 | P = 0.22 | |||
| IOP (mmHg) | 17.1 ± 2.3 | 13.7 ± 1.5 | 14.0 ± 2.0 | 14.4 ± 2.0 | P < 0.001 | P < 0.001† | P < 0.001† | P < 0.001† |
| OPP (mmHg) | 39.5 ± 8.3 | 40.8 ± 9.3 | 42.9 ± 8.6 | 44.1 ± 9.4 | P = 0.68 | |||
| sBP (mmHg) | 116.0 ± 18.0 | 111.0 ± 19.5 | 118.4 ± 20.2 | 120.9 ± 18.9 | P = 0.071 | |||
| dBP (mmHg) | 69.2 ± 11.0 | 67.2 ± 12.1 | 68.8 ± 15.9 | 71.1 ± 13.0 | P = 0.75 | |||
Values comprise mean ± standard deviation.
ANOVA = analysis of variance; pBFV = parafoveal retinal blood flow velocity; MBRT = mean blur rate in the tissue area of the optic nerve head; RVDA = retinal vessel diameter of artery; RVDV = retinal vessel diameter of vein; IOP = intraocular pressure; OPP = ocular perfusion pressure; sBP = systolic blood pressure; dBP = diastolic blood pressure.
*Comparison was performed using the paired t-test.
†Significant differences after Bonferroni’s correction are indicated.