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. 2017 Jul 10;7:4955. doi: 10.1038/s41598-017-05285-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison between detection of amyloid plaques by Gd-stained MRI and immunohistochemistry in APP_SL/PS1_M146L, APP/PS1_dE9, and APP23 mice. Gd-stained in vivo (column 1) or ex vivo (column 2) MR images were registered with β-amyloid (BAM10, column 3) and iron-stained (Perls-DAB, column 4) histological sections in APP_SL/PS1_M146L (A–D), APP/PS1_dE9 (E–H) and APP23 (I–L) mice. Inserts in columns 3 and 4 display typical plaques for each strain. Hypointense spots (white arrows and circles) are visible in the in vivo and/or ex vivo MR images of APP_SL/PS1_M146L (A,B), APP/PS1_dE9 (E,F) and APP23 (I,J) mice. They can be registered with amyloid plaques (black and red arrows and circles) on BAM10-stained sections (C,G,K). Iron staining reveals iron deposits that can be registered with hypointense spots and amyloid plaques in APP_SL/PS1_M146L (D), APP/PS1_dE9 (H) and APP23 (L) mice. Some amyloid plaques containing iron (black arrows and circles) are visible on MR images. Some others are iron-free (red arrows) and are also detected by MRI indicating that iron is not necessary for MR detection. Scale bars: 500 µm for main images and 50 µm for inserts.