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. 2017 Jul 10;7:4955. doi: 10.1038/s41598-017-05285-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detectability of amyloid plaques by Gd-stained MRI according to their iron content. Cortical amyloid plaques with a diameter ≥36 µm were categorized into one of the following four categories: iron-positive plaques detected by MRI (MRI + Iron +, black), iron-negative plaques detected by MRI (MRI + Iron −, red), iron-positive plaques not detected by MRI (MRI − Iron+, grey) and iron-negative plaques not detected by MRI (MRI − Iron −, pink) in APP_SL/PS1_M146L, APP/PS1_dE9 and APP23 mice (A). Among amyloid plaques detected by Gd-stained MRI, 59%, 75% and 68% contained iron in APP_SL/PS1_M146L, APP/PS1_dE9 and APP23 mice, respectively (B). Among amyloid plaques not detected by Gd-stained MRI, 50%, 71% and 50% contained iron in APP_SL/PS1_M146L, APP/PS1_dE9 and APP23 mice, respectively (C).