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. 2017 Jul 10;7:4972. doi: 10.1038/s41598-017-05212-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Improved antipneumococcal resistance in pre-diseased SPC-HAxTCR-HA mice. Mice were oropharyngeally inoculated with ~1.5 × 10⁴ CFU S. pneumoniae TIGR4 and were sacrificed at the indicated time points. The bacterial burden in bronchoalveolar lavage fluid (BALF) (a) and lung tissue homogenates (b) was determined. BALF and lung homogenates were taken from the same mice. Data were pooled from 2 independent experiments. Dashed lines indicate the detection limit. *p < 0.05. (c) Mice were oropharyngeally inoculated with ~1.5 × 10⁶ CFU S. pneumoniae TIGR4 and survival was followed over a period of 14 days. *p < 0.05 (n = 15/group, 2 independent experiments).