Figure 1.

In vitro uptake of ¹⁸F-FDG by different bacteria. The mean uptake of ¹⁸F-FDG by clinical isolates of different Gram-positive (A) and Gram-negative (B) bacteria was expressed as absorbed activity in Bq/10⁷ CFUs. (C) Total uptake in kBq of ¹⁸F-FDG by S. aureus, E. coli or S. pneumoniae in comparison to heat-killed bacteria, bacteria not incubated with ¹⁸F-FDG, and medium controls. The indicated standard deviations include the variations introduced by the use of at least two different isolates per tested species. Note that the detection limit for a bacterial species will lie between the nonspecifically absorbed activity measured for heat-killed bacteria, such as E. coli and S. aureus, and the lowest level of ¹⁸F-FDG uptake by the living bacteria, such as S. pneumoniae. This implies that under the tested conditions, the detection limit is ~2.4 kBq. *p ≤ 0.01. Values represent mean ± SEM (n = 8).