Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 10;7:4943. doi: 10.1038/s41598-017-05213-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Conditional deletion of PDK1 in a hematopoietic system results in increased HSCs but reduced progenitors. (A,B) Representative FACS plots and histograms showing the frequency of LKs (Lin⁻c-kit⁺Sca-1⁻ cells) and LSKs (Lin⁻c-kit⁺Sca-1⁺ cells) in BM from WT and PDK1^Δ/Δ mice. (C,D) Representative FACS plots and histograms showing the frequency of LT-HSCs, ST-HSCs and MPPs in LSKs from WT and PDK1^Δ/Δ mice. (E) Representative FACS plots showing the frequency of GMPs, CMPs and MEPs in BM from WT and PDK1^Δ/Δ mice. (F) Representative histograms showing the frequency of CMPs, GMPs, MEPs and CLPs in LKs from WT and PDK1Δ/Δ mice. The data are shown as the mean ± SD (n = 5); *P < 0.05; **P < 0.01; ***P < 0.001; NS, not significant.