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. 2017 Jul 10;7:4977. doi: 10.1038/s41598-017-05337-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MD-induced spine elimination depends on the competitive interactions between the deprived and non-deprived eye. (A) Schematic of experimental design to examine the effect of MD in the monocular region of the primary visual cortex. (B) No significant difference in spine elimination or formation over 3 days between MD mice and non-deprived control mice (n = 713 spines, 30 dendrites from 4 MD mice, n = 653 spines, 30 dendrites from 4 control mice). (C) Schematic of experimental design to examine the effect of BD in the binocular region of the primary visual cortex. BD represents binocular deprivation. (D) No significant difference in spine elimination or formation over 3 days between BD and non-deprived control mice (n = 1023 spines, 47 dendrites from 6 BD mice, n = 1096 spines, 42 dendrites from 6 control mice). Data are presented as mean ± SEM. n.s. = not significant.