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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Mar 27;1862(6):636–645. doi: 10.1016/j.bbalip.2017.03.010

Figure 6. Proposed cascade of events in the pathogenesis of diabetic retinopathy.

Figure 6

Hyperglycemia activates 12/15-LO to release 12- and 15-hydroxyeicosatetraeanoic acids (HETEs) that in turn activate retinal endothelial cells through various inflammatory signaling system leading to increases in ICAM-1 expression, leukocyte adhesion, followed by hyperpermeability, the cardinal signs of diabetic retinopathy.