Syntheses of compound 8p and 8qa
aReagents and conditions (a) MeNH(OMe)•HCl, EDCI, Et3N, CH2Cl2, 41% (b) BnMgCl, THF, 0 °C to RT, 25%. (c) IBCF, NMM, THF, 0 °C, then aq. NaBH4, 0 °C, 41%. (d) MsCl, Et3N, THF, 0 °C. (e) aniline, Et3N, THF, 20% (2 steps).