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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: J Med Chem. 2017 Mar 13;60(6):2305–2325. doi: 10.1021/acs.jmedchem.6b01568

Scheme 6.

Scheme 6

Synthesis of compound 9aa

aReagents and conditions (a) EDCI, HOBt, 3-methylfuran-2-carboxylic acid, DMF, RT, 65%. (b) NaOH, H2O/MeOH/THF, then aq. HCl, RT. (c) EDCI, HOBt, aniline, DMF, RT, 54% (2 steps)