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. Author manuscript; available in PMC: 2017 Jul 11.

Published in final edited form as: J Med Chem. 2017 Mar 13;60(6):2305–2325. doi: 10.1021/acs.jmedchem.6b01568

Scheme 1 — General synthesis of compounds 1a–1s and syntheses of compound 1t and 1u

^aReagents and conditions (a) EDCI, HOBt, aniline, DMF, RT, 65%. (b) PhSH, Cs₂CO₃, CH₃CN, RT, 50%. (c) EDCI, HOBt, R¹COOH, DMF, RT, 22–87%. (d) 3-methyl-2-furaldehyde, NaBH(OAc)₃, AcOH, DMA, 60°C, 13%. (e) furan-2-sulfonyl chloride, DIPEA, CH₂Cl₂, 0°C to RT, 58%