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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: J Med Chem. 2017 Mar 13;60(6):2305–2325. doi: 10.1021/acs.jmedchem.6b01568

Table 2.

RSV inhibitory (EC50) and cytotoxic (CC50) concentrations and selectivity indices (SI) of 1a analogs featuring modifications of section C.a

graphic file with name nihms873878u3.jpg
Compound No. Y R2 EC50 [µM] CC50 [µM] SI
8a C=O graphic file with name nihms873878t24.jpg 10 >90 >9
8b C=O graphic file with name nihms873878t25.jpg 1.2 (0.79 to 1.84) 50 42
8c C=O graphic file with name nihms873878t26.jpg 0.06 (0.04 to 0.1) 5 83
8d C=O graphic file with name nihms873878t27.jpg 0.14 (0.08 to 0.2) 1.1 8
8e C=O graphic file with name nihms873878t28.jpg 0.28 (0.21 to undef) 3.3 12
8f C=O graphic file with name nihms873878t29.jpg 0.41 (0.35 to 0.51) 30 73
8g C=O graphic file with name nihms873878t30.jpg 0.05 (0.03 to 0.08) 1.1 22
8h C=O graphic file with name nihms873878t31.jpg 0.21 (0.15 to 0.3) 30 143
8i C=O graphic file with name nihms873878t32.jpg 0.33 (0.26 to 0.4) 90 273
8j C=O graphic file with name nihms873878t33.jpg 0.31 (0.16 to 0.6) 3.3 11
8k C=O graphic file with name nihms873878t34.jpg 0.54 (0.17 to 1.7) 30 56
8l C=O graphic file with name nihms873878t35.jpg 0.32 (0.26 to 0.4) 90 281
8m C=O graphic file with name nihms873878t36.jpg >10 ND ND
8n C=O graphic file with name nihms873878t37.jpg 0.06 (0.002 to 1.7) 30 500
8o C=O graphic file with name nihms873878t38.jpg 1.53 (0.71–3.33) 16.6 11
8p C=O graphic file with name nihms873878t39.jpg 0.07 (0.06 to 0.09) 5.5 79
8q CH2 graphic file with name nihms873878t40.jpg 0.5 (0.39 to 0.6) 10 20
8r SO2 graphic file with name nihms873878t41.jpg >10 ND ND
8s NH graphic file with name nihms873878t42.jpg >10 ND ND
8t NH graphic file with name nihms873878t43.jpg >10 ND ND
a

Testing and analysis were carried out as specified for table 1.