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RSV inhibitory (EC50) and cytotoxic (CC50) concentrations and selectivity indices (SI) of 1a analogs featuring modifications of section B or modifications of multiple sections.a
| Compound No. | Structure | EC50[µM] | CC50[µM] | SI |
|---|---|---|---|---|
| 9a |
|
>10 | ND | ND |
| 9b |
|
3.19 (2.4 to 4.2) | >90 | >28 |
| 9c |
|
0.32 (0.21 to 0.5) | 3.7 | 12 |
Testing and analysis were carried out as specified for table 1.
