Table 4.

Aqueous solubility for selected compounds at various pH values^a

Compound No.	Structure	Aq. Solubility (µg/mL)			Metabolic Stability (t1/2)
		pH			Mouse		Human
		7.4	5.0	3.0	liver S9	plasma	liver micro somes	plasm a
1a		63	75	74	15 min	-	4.7 h	-
8g		30	51	75	11 min	2.4 h	5.3 h	>24 h
8p		18	18	<15	20 min	-	42 min	-
8n					4 minb		3.6 h
8a		58	25	20
8j		28	43	48

^aDetailed solubility and metabolism procedures in Experimental Section

^bTested against mouse liver microsomes