Table 5.
Major metabolites of 8p by mouse liver microsomes and proposed biotransformationsa
| Metabolit e |
Retention Time (min) |
m/z (Δ Da) | Proposed Biotransformation | Proposed Site of Biotransformation |
|---|---|---|---|---|
| M1 | 7.0 | 556 (+192) | Glucuronide of M3 | Phenyl ring hydroxyl |
| M2 | 9.7 | 396 (+32) | (di)hydroxylation/N-oxide(s) | Pyrazole ring |
| M3 | 10.1 | 380 (+16) | Monohydroxylation | Phenyl ring |
| M4 | 10.6 | 380 (+16) | Monohydroxylation or N-oxide | Pyrazole ring |
| Parent | 12.9 | 364 (MH+) | Parent | N/A |
a
Detailed procedure in Supporting Information