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. 2017 Mar 31;143(8):1585–1596. doi: 10.1007/s00432-017-2402-x

Table 2.

Drug exposure

Young (n = 243) Middle age (n = 494) Elderly (n = 300) Old (n = 52)
Duration of exposure, days (median, range) 722.00 (46–821) 724 (5–793) 724 (1–798) 709 (4–780)
Time of treatment, days (median, range) 728 (46–960) 728 (5–888) 728 (1–817) 718 (4–780)
Average daily dose, mg/day, (mean ± SD) 583.1 ± 50.7 587.0 ± 46.4 577.6 ± 66.4 576.5 ± 64.9
Dose intensity, mg/day (median, range) 600 (257.8–620.5) 600 (144.4–689.0) 600 (173.9–625.7) 598.5 (300.0–600.0)
Dose reductions, n (%) 71 (29.2%) 146 (29.6%) 90 (30.0%) 14 (26.9%)
 1 Dose reduction 32 (13.2) 76 (15.4) 46 (15.3) 6 (11.5)
 2 Dose reductions 15 (6.2) 30 (6.1) 20 (6.7) 5 (9.6)
 >2 Dose reductions 24 (9.9) 40 (8.1) 24 (8) 3 (5.8)
Dose interruptions, n (%) 84 (34.6%) 168 (34.0%) 113 (37.7%) 22 (42.3%)
 1 Dose interruption 39 (16.1) 95 (19.2) 57 (19.0) 14 (26.9)
 2 Dose interruptions 20 (8.2) 44 (8.9) 21 (7.0) 4 (7.7)
 >2 Dose interruptions 25 (10.3) 29 (5.9) 35 (11.7) 4 (7.7)